Juliette Hadchouel Selected Research

Member 3 Solute Carrier Family 12

1/2018	Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC.
1/2017	Double Knockout of the Na+-Driven Cl-/HCO3- Exchanger and Na+/Cl- Cotransporter Induces Hypokalemia and Volume Depletion.
8/2015	The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride.
11/2014	WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
3/2012	KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron.
1/2012	Pathogenesis of pseudohypoaldosteronism type 2 by WNK1 mutations.
10/2010	Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Juliette Hadchouel Research Topics

Disease

22	Hypertension (High Blood Pressure) 12/2020 - 12/2003
6	Hyperkalemia 12/2020 - 01/2005
5	Acidosis 12/2020 - 01/2005
4	Pseudohypoaldosteronism 01/2018 - 01/2005
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2018 - 01/2016
2	Hypokalemia 01/2017 - 04/2006
1	Aortic Rupture 01/2022
1	Type IV Ehlers-Danlos Syndrome 01/2022
1	Fibrosis (Cirrhosis) 01/2019
1	Kidney Diseases (Kidney Disease) 01/2019
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2019
1	Renal Tubular Acidosis (Distal Renal Tubular Acidosis) 01/2018
1	Hypercholesterolemia 03/2015
1	Hereditary Sensory and Autonomic Neuropathies (HSAN) 01/2012
1	Heart Diseases (Heart Disease) 09/2011
1	Essential Hypertension 09/2011
1	Hypotension (Low Blood Pressure) 01/2011
1	Hypovolemia 10/2010
1	Hyperaldosteronism (Conn Syndrome) 04/2006
1	Gordon syndrome 01/2005

Drug/Important Bio-Agent (IBA)

9	Lysine (L-Lysine)FDA Link 12/2020 - 08/2005
8	Phosphotransferases (Kinase)IBA 01/2018 - 12/2003
7	Member 3 Solute Carrier Family 12IBA 01/2018 - 10/2010
4	ReninIBA 01/2019 - 01/2005
3	Cullin Proteins (Cullins)IBA 01/2019 - 08/2012
3	AldosteroneIBA 01/2011 - 04/2006
2	Angiotensin IIIBA 01/2022 - 03/2015
2	Potassium Channels (Potassium Channel)IBA 01/2018 - 08/2013
2	Sodium Chloride Symporter Inhibitors (Diuretics, Thiazide)IBA 01/2018 - 01/2005
2	ThiazidesIBA 01/2018 - 01/2017
2	SaltsIBA 03/2015 - 01/2011
1	Collagen Type III (Type III Collagen)IBA 01/2022
1	Amlodipine (Norvasc)FDA LinkGeneric 01/2022
1	Hydralazine (Apresoline)FDA LinkGeneric 01/2022
1	Antihypertensive Agents (Antihypertensives)IBA 01/2022
1	CollagenIBA 01/2022
1	Losartan (Cozaar)FDA LinkGeneric 01/2022
1	Connexin 43 (Connexin43)IBA 01/2019
1	WNK Lysine-Deficient Protein Kinase 1IBA 01/2019
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2019
1	Discoidin Domain Receptor 1IBA 01/2019
1	PeriostinIBA 01/2019
1	Bicarbonates (Hydrogen Carbonate)IBA 01/2018
1	Sodium Chloride FDA LinkGeneric 01/2018
1	Chloride-Bicarbonate AntiportersIBA 01/2017
1	ChloridesIBA 01/2016
1	ElectrolytesIBA 01/2016
1	Ligases (Synthetase)IBA 01/2016
1	NG-Nitroarginine Methyl Ester (L-NAME)IBA 03/2015
1	Acetates (Acetic Acid Esters)FDA Link 03/2015
1	PCSK9 InhibitorsIBA 03/2015
1	Desoxycorticosterone (Deoxycorticosterone)IBA 03/2015
1	SodiumIBA 03/2015
1	Desoxycorticosterone Acetate (DOCA)FDA Link 03/2015
1	Epithelial Sodium ChannelsIBA 08/2013
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2012
1	MicroRNAs (MicroRNA)IBA 09/2011
1	AcidsIBA 01/2011
1	Protein Isoforms (Isoforms)IBA 10/2010

Therapy/Procedure

2	Therapeutics 01/2022 - 01/2019
1	Transplantation 01/2019
1	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2019